Preparing a Suitable Solid Target for Generating Copper-64 Using a Biomedical Cyclotron

  • Ms Charmaine Jeffery, Sir Charles Gairdner Hospital, Australia
  • Mr David Cryer, Sir Charles Gairdner Hospital, Australia
  • Mr Sun Chan, Sir Charles Gairdner Hospital, Australia
  • Mr Ali Asad, Sir Charles Gairdner Hospital, Australia
  • Mr Adam Fleming, University of Western Australia, Australia
  • Mr Lee Hubble, University of Western Australia, Australia

    • Radiopharmaceutical research at SCGH has been advancing in the production of copper-64, a promising radionuclide for PET. Production has commenced using a self-manufactured solid target with a IBA 18/9 cyclotron, via the 64Ni(p,n)64Cu reaction pathway. One aspect of the project has been the preparation of a suitable solid target for irradiation.

    The chosen production method involves electrolysis of a solution of nickel ammonium sulphate in a self-manufactured electroplating cell, using a gold disk as the cathode for deposition of nickel metal.

    Various defects in the nickel surface were observed – including cracks, formation of pits and inclusions, loose powder-like plating, lack of metallic lustre and lifting of the plated nickel. Several variables were investigated – including adjustment of the anode-cathode distance, anode composition, solution composition, and voltage/current settings. A suitable method that produced acceptable plating was achieved – the surface was then analysed to ensure there were no underlying defects.

    Three analytical techniques were used - AFM, SEM and optical profilometry. Two disks were analysed (approx. 30mg of natNi plated). The depth of plating, evenness of plating and surface uniformity were of particular interest.

    Conclusions: Analysis revealed that the surface was not completely uniform (thinner at edges, ‘well’ in centre, with inclusions on the surface more prevalent than pitting), and required more nickel to be plated to reach optimum thickness. Final target specifications are still being optimised, however test irradiation of a solid target (
    natnickel, 110mg) proved that a sound solid target can be reliably produced and irradiated.